Pharmacokinetics of ceftiofur after single intravenous and intramuscular administration of ceftiofur sodium to dairy goats

كتاب Pharmacokinetics of ceftiofur after single intravenous and intramuscular administration of ceftiofur sodium to dairy goats


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The Arabian camel (Camelus dromedarius) is an important domestic animal in arid and semi-arid zones. It is used in pastoral societies as a source of meat, hair, hides and milk and for draught and transport. In gulf countries, it is used in sport races, and in other countries, it is a popular zoo animal (Ali et al., 1996). Antibacterial drugs are used in both treatment and prevention programmes for bacterial diseases of camel. Ceftiofur is a semisynthetic third generation cephalosporin, is a broadspectrum antibiotic against both Gram-positive and Gramnegative bacteria including beta-lactamase-producing bacterial strains and some anaerobic bacteria and it is less active against Pseudomonas aeruginosa (Brown et al., 1991; Prescott, 2000). Its antibacterial activity results from the inhibition of mucopeptide synthesis in the cell wall in a similar fashion to other cephalosporins. The thioester bond on ceftiofur is rapidly cleaved to give desfuroylceftiofur, which is further metabolized to a disulfide dimer and various desfuroylceftiofur-protein and amino acid conjugates (Jaglan et al., 1990; Beconi-Barker et al.,



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