الكاتب: Multiple References

Mechanism of action/Effect: Like other coxib anti-inflammatories, firoxocib is a cyclooxygenase inhibitor. In vitro studies have shown it to be highly selective for cyclooxygenase-2 (COX-2), which is responsible for the production of inflammatory mediators, and very sparing of cyclooxygenase-1 (COX-1), which is involved in production of prostaglandins for maintenance of physiologic functions, including gastric cytoprotection, renal homeostasis, and normal platelet function.{R-1; 4} However, the relationship between these in vitro results and the clinical effects and safety of nonsteroidal anti-inflammatories has not been completely defined.{R-1}